A Synaptic Vesicle-Associated Protein (SVP-38) as an Early Indicator of Delayed Neuronal Death
نویسندگان
چکیده
منابع مشابه
Delayed Synaptic Changes in Axotomized Spinal Motoneurons of Newborn Rats Associated with Progressive Neuronal Loss: Immunohistochemical, Ultrastructural, and Quantitative Study
Background and Objective: Sciatic nerve transection is characterized by a rapid wave of motoneuron death associated with progressive synaptic lesions. The purpose of this study was to evaluate the long term synaptic changes. Materials and Methods: This basic study was carried out on paraffin- or resin-em...
متن کاملDefect in Synaptic Vesicle Precursor Transport and Neuronal Cell Death in KIF1A Motor Protein–deficient Mice
The nerve axon is a good model system for studying the molecular mechanism of organelle transport in cells. Recently, the new kinesin superfamily proteins (KIFs) have been identified as candidate motor proteins involved in organelle transport. Among them KIF1A, a murine homologue of unc-104 gene of Caenorhabditis elegans, is a unique monomeric neuron- specific microtubule plus end-directed moto...
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ISSUE A novel mechanism of action has recently been described for levetiracetam, a member of a new class of anticonvulsants. Levetiracetam binds selectively and with high affinity to a synaptic vesicle protein known as SV2A, thought to be involved with synaptic vesicle exocytosis and presynaptic neurotransmitter release.
متن کاملTRPV1 acts as a synaptic protein and regulates vesicle recycling.
Electrophysiological studies demonstrate that transient receptor potential vanilloid subtype 1 (TRPV1) is involved in neuronal transmission. Although it is expressed in the peripheral as well as the central nervous system, the questions remain whether TRPV1 is present in synaptic structures and whether it is involved in synaptic processes. In the present study we gathered evidence that TRPV1 ca...
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Praggastis, Sophia, "Vesicle-associated membrane protein (VAMP)/synaptobrevin-2 protein mutants functionality test in synaptic vesicle fusion" (2014). Undergraduate Honors Theses. Paper 181.
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1995
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1995.57